In this article, we propose the Fair Priority Model for COVID-19 vaccine distribution, and emphasize three fundamental values we believe should be considered when distributing a COVID-19 vaccine among countries: Benefiting people and limiting harm, prioritizing the disadvantaged, and equal moral concern for all individuals. The Priority Model addresses these values by focusing on mitigating three types of harms caused by COVID-19: death and permanent organ damage, indirect health consequences, such as health care system strain and stress, as well as (...) economic destruction. It proposes proceeding in three phases: the first addresses premature death, the second long-term health issues and economic harms, and the third aims to contain viral transmission fully and restore pre-pandemic activity. -/- To those who may deem an ethical framework irrelevant because of the belief that many countries will pursue "vaccine nationalism," we argue such a framework still has broad relevance. Reasonable national partiality would permit countries to focus on vaccine distribution within their borders up until the rate of transmission is below 1, at which point there would not be sufficient vaccine-preventable harm to justify retaining a vaccine. When a government reaches the limit of national partiality, it should release vaccines for other countries. -/- We also argue against two other recent proposals. Distributing a vaccine proportional to a country's population mistakenly assumes that equality requires treating differently situated countries identically. Prioritizing countries according to the number of front-line health care workers, the proportion of the population over 65, and the number of people with comorbidities within each country may exacerbate disadvantage and end up giving the vaccine in large part to wealthy nations. (shrink)

Current UK legislation is impacting upon the feasibility and cost-effectiveness of medical record-based research aimed at benefiting the NHS and the public heath. Whereas previous commentators have focused on the Data Protection Act 1998, the Health and Social Care Act 2001 is the key legislation for public health researchers wishing to access medical records without written consent. The Act requires researchers to apply to the Patient Information Advisory Group for permission to access medical records without written permission. We present (...) a case study of the work required to obtain the necessary permissions from PIAG in order to conduct a large scale public health research project. In our experience it took eight months to receive permission to access basic identifying information on individuals registered at general practices, and a decision on whether we could access clinical information in medical records without consent took 18 months. Such delays pose near insurmountable difficulties to grant funded research, and in our case £560 000 of public and charitable money was spent on research staff while a large part of their work was prohibited until the third year of a three year grant. We conclude by arguing that many of the current problems could be avoided by returning PIAG’s responsibilities to research ethics committees, and by allowing “opt-out” consent for many public health research projects. (shrink)

De Bie et al. (2023) propose an organizing framework for different stages of human gestational development from conception to the viable premature. They also identify ethical considerations and con...

Changes in pupil size can reflect social interest or affect, and tend to get mimicked by observers during eye contact. Pupil mimicry has recently been observed in young infants, whereas it is unkno...

Locke's main semantic thesis is that words stand for, or signify, ideas. He says this over and over again, though the phraseology he employs varies. In Book III chapter 2 alone we find the following statements of the thesis: ‘ … Words … come to be made use of by Men, as the Signs of their Ideas’ [III.2.1; 405:10-11); The use then of Words, is to be sensible Marks of Ideas; and the Ideas they stand for, are their proper and (...) immediate Signification’ [III.2.1; 405:15-17]; ‘Words in their primary or immediate Signification, stand for nothing, but the Ideas in the Mind of him that uses them’ [III.2.2; 405:21-2]; That then which Words are the Marks of, are the Ideas of the Speaker’ [III.2.2; 405:27-8]; ‘ …. (shrink)

This is the first full-length translation of a work by the influential medieval logician Walter Burley. As such, it is an important addition to our knowledge of medieval logic, and will undoubtedly spur further research.

This chapter focuses on John Locke's relation to scholasticism. It explores who the schoolmen referred to by Locke were, and what he might have learned from them, particularly with respect to topics in metaphysics, logic, and language. The chapter considers the Oxford curriculum which provided the framework for Locke's years of study and teaching there, as there is little reason to believe that he enriched his acquaintance with the schoolmen in his later career. The topic of substance was raised both (...) in metaphysics textbooks and in logic textbooks, but the material in both was largely similar. The chapter considers some of Locke's remarks and focuses on what the scholastics had to say. Locke goes on to claim that the very use of syllogistic depends on the prior ability to see the connections between ideas. The area in which Locke showed the most obvious influence of scholasticism is that of language. (shrink)

When Kepler concluded that the orbit of Mars was not a circle, he was led to the belief that the orbit was an oval touching the circle at the apsides and lying within the circle at other points. In the definition of the oval, physical hypotheses played a primary role. Two forces were involved; a tractive force arising from the effect of the solar rays rotating with the sun, and a directing force arising from a natural instinct of the planet (...) itself. The former pushed the planet along the orbit while the latter enabled the planet to steer itself across the stream of the solar vortex in a small epicycle. In adopting this physical theory to determine the oval, Kepler was led into what he himself described as ‘a new labyrinth’. After several attempts to construct the oval, and by progressively eliminating the sources of error from his calculating procedures in order to arrive at an accurate mathematical formulation of the physical hypotheses, he was able to conclude that the oval was inconsistent with the empirical data and the physical theory in need of modification. (shrink)